Dissociation of estrogen (E2) effects on the vasculature of diabetic rats

• DOI: 10.1096/fasebj.22.1_supplement.1148.6
• Publication Date: 2021-06-21T23:20:01Z
• Authors: Adam Mitchell; Jennifer Rogers; Adam Myers; Susan Mulroney
• Keywords: Vasoprotective; Myograph

Decreases in circulating estrogen seen human female diabetics may exacerbate vascular impairment the hyperglycemic state alone. E2s role as a vasoprotective agent is not clear. In normal animals, we and others have shown that E2 increases NO production while decreases sensitivity to vasodilator ACh vasoconstrictor PE. To examine whether there dysregulation of affect diabetic (D) vasculature, diabetes was induced by STZ injection adult rats concurrent with ovariectomy (OVX) replacement. After 8 weeks, mesenteric arteriolar reactivity PE measured on wire myograph. (p<0.01) vs non‐diabetic (ND) vessels. While OVX reverses this effect (p=0.04), replacement same . Similarly, (p=0.02), (p=0.03), alone different than prevented STZ‐induced both GSI (~30%) TIFI (~20%), indicating efficacy D kidney. These data confirm effects ND (reported our lab), extend findings showing lost resistance vessels, but This dissociation early predispose development complications.