Preservation of endothelial cell/pericyte adhesion by cilostazol in ischemic limb of diabetic mouse

• DOI: 10.1096/fasebj.22.1_supplement.1226.15
• Publication Date: 2021-06-21T23:37:53Z
• Authors: Tomoharu Suzuki; Shonosuke Matsushita; Haruhiko Sugimori; Fujio Sato; Yuzuru Sakakibara
• Keywords: Cilostazol; Pericyte

Purpose: Degeneration of pericytes and acellular capillaries are increased in the feet human diabetic patients. Selective loss adhesion pericyte to endothelial cell is known early event microangiopathy. In diabetes, inflammation due dysfunction augmented. Cilostazol, a PDE III inhibitor, reported reduce oxidative stress Based on these findings, we investigated effect cilostazol endothelial/pericyte ischemic hindlimb mice. Method: Type I diabetes was induced by intraperitoneal administration streptozocin (50mg/kg) for five days both cilostazol‐fed mice control‐diet‐fed Resection femoral artery conducted develop ischemia. Ten after procedure, gastrocnemius muscles were resected. Adhesion assessed transmission electron microscopy. Result: The rate detachment between 1/15, whereas it 9/8 non‐cilostazol‐fed (p<0.005). Conclusion: Cilostazol preserved cell/pericyte limb mouse. may provide improvement capillary morphology foot addition vasodilation.