Hyperthermia significantly increases ventilatory response to isocapnic hypoxia in humans

• DOI: 10.1096/fasebj.22.2_supplement.130
• Publication Date: 2019-12-30T16:59:00Z
• Authors: Matthew Kim; Luisa V. Giles; Michael S. Koehle; Matthew D. White
• Keywords: Hypoxia; Hypoxic ventilatory response

Purpose: To investigate the influence of hyperthermia on ventilatory responses to isocapnic hypoxia (iHVR). Methods and Study Design: Four males volunteered for study that was approved by SFU Office Research Ethics. Each participant instrumented esophageal surface skin temperatures had his expired gases analyzed indirect calorimetry. The protocol included two iHVR trials, one in normothermia hyperthermia. Prior each trial rested a seated position 30 min. This period ended with collection 5 min pre-iHVR ventilation temperature data. Normothermic trials were performed an (TES) ∼ 37.0°C, whereas during hyperthermic passively heated climatic chamber (50°C, 20% RH) TES ∼39.5°C. administered single step PETO2 50 mmHg 20 For both PETCO2 maintained 1 above resting level established prior normothermic trial. Results: Mean pre 13.5±2.4 L/min (mean ± SD) this increased mean 20.4±2.1 Following passive heating trial, 26.5±4.8 L/min. 38.8±6.4 There significant increases (p=0.003) (p=0.02) relative condition. Conclusions: Hyperthermia humans significantly elevates hypoxia. supported grants from Natural Sciences Engineering Council Canada Canadian Foundation Innovation.