Iron bioavailability from maize‐based diets fed to iron deficient broiler chickens

• DOI: 10.1096/fasebj.24.1_supplement.208.8
• Publication Date: 2021-06-15T17:59:51Z
• Authors: Elad Tako; Mercy Lung'aho; Leon V Kochian; Owen A Hoekenga; Raymond P Glahn
• Keywords: Biofortification; Ferroportin

Iron biofortification is a strategy that alleviates Fe deficieny by improving staple crops, such as maize (Zea mays). Using Caco2 cell model, two varieties were developed for high and low bioavailability. In vitro observations should be tested in animals prior to human efficacy studies. We bioavailable our using the broiler chicken model. Diets made with 75% w/w of either (“Low”) or (“High”) bioavailability maize; content was not different (both 24 μg/g). analysis showed lower ferritin formation (ie. uptake, P<0.05) cells exposed “Low” (20 ng/mg) vs. “High” (37 diets. Chicks (n=6) fed based diets 4 weeks. Hemoglobin (Hb), body weight, feed consumption gene expression measured. Duodenal DMT1, Dcytb ferroportin higher (P<0.05) group group, indicating adaptation diet. Hb concentrations, hemoglobin maintenance efficiency, Hb‐Fe liver “High“ (P<0.05), greater absorption from diet improved status. conclude vivo results support observations, ie. variety contains more than ”Low” shows promise biofortification.