Cocaine dose and self‐administration history, but not initial cocaine‐induced locomotor responsiveness, affect sensitization to the motivational effects of cocaine in rats

• DOI: 10.1096/fasebj.26.1_supplement.659.13
• Publication Date: 2021-06-21T15:51:30Z
• Authors: Bruce H Mandt; Emily Gomez; Nickie L Johnston; Nancy R Zahniser; Richard M Allen
• Keywords: Self-administration; Behavioral sensitization; Affect; Locomotor activity; Drug intoxication

Cocaine addiction is a significant and complex disease. Part of this complexity due to variability the drug experience early in use (e.g., initial responsiveness, amount use, etc.). In rats, individual differences cocaine responsiveness self‐administration history both predict development sensitization, putative mechanism contributing addiction. Here we sought determine role these factors dose on sensitization cocaine's motivational effects during earliest stages self‐administration. Rats were classified as either low or high responders (LCRs HCRs, respectively) based acute cocaine‐induced locomotor activity (10 mg/kg, IP) before learning self‐administer (0.75 mg/kg/IV inf) under fixed ratio 1 (FR1) schedule. Following acquisition, rats advanced progressive (PR) testing 1.5 mg/kg/inf cocaine) immediately after an additional 5 FR1 sessions cocaine). No LCR/HCR found. However, exposure higher schedules produced (i.e., increased break points). Thus, our results reveal suggest process may occur very This work was supported by NIH Grants R01 DA004216 K05 DA015050 ASPET SURF award.