Nebivolol reduces intracellular Ca2+ and elicits dilations in isolated rat basilar arteries (1070.7)

• DOI: 10.1096/fasebj.28.1_supplement.1070.7
• Publication Date: 2021-06-16T09:47:24Z
• Authors: Peter Cseplo; Zoltan Vamos; Istvan Batai; Orsolya Torok; Zsolt Springo; Attila Toth; Akos Koller
• Keywords: Nebivolol; Myograph

Experimental and clinical studies have revealed that the antiarrhythmic antihypertensive, highly selective β1‐adrenerg receptor blocker, nebivolol elicits dilations in peripheral arteries, which a role for nitric oxide (NO) has been implicated. However, its effect on diameter of cerebral vessels not investigated. We hypothesized increases isolated arteries. Basilar arteries (BA) were from male Wistar rats mounted into isotonic myograph chamber. Diameters measured by video‐microscopy response to vasoactive agents, intravascular Ca2+ changes was detected fura‐2 ratiometric method. Nebivolol elicited significant vasodilation, despite presence L‐NAME (NOS inhibitor) or ODQ (guanylate cyclase blocker) SQ22536 (adenylyl blocker). significantly reduced calcium‐signal correlated with diameter. In BA nebivolol: 1) dilation, 2) NO‐cGMP/cAMP pathway does contribute significantly, 3) decreases vascular wall [Ca2+]i. (Supported by: OTKA K108444, SROP‐4.2.2.A‐11/1/KONV‐2012‐0024, SROP‐4.2.2.A‐11/1/KONV‐2012‐0017, TAMOP 4.2.4.A/2‐11‐1‐2012‐0001 “National Excellence Program”) Grant Funding Source : „National Program”