Iron biofortified beans improve iron status in Rwandan University women: results of a feeding trial (646.1)

• DOI: 10.1096/fasebj.28.1_supplement.646.1
• Publication Date: 2021-06-16T10:01:14Z
• Authors: Jere Haas; Sarah Luna; Mercy Lung'aho; Fidel Ngabo; Michael Wenger; Laura Murray‐Kolb; Steve Beebe; Jean‐Bosco Gahutu; Ines Egli
• Keywords: Soluble transferrin receptor; Biofortification

Objective : To examine the efficacy of an iron biofortified bean intervention on status in depleted young women. Methods 257 Rwandan university women (18‐27 y) with screening ferritin <20 μg/L were randomized to consume ~155 g/d, dry wt. either beans (Fe=78 mg/g) or control (Fe=59 per day for 135 days. Iron (hemoglobin‐ Hb , ferritin‐ Fer transferrin receptor‐ TfR body iron‐ BI ), inflammation ( CRP, AGP and anthropometric indices determined at enrollment, 7 random midpoints after Difference‐in‐difference analysis plus repeated measures ANOVA linear binomial regression models used evaluate effect status. Results At baseline, 231 study subjects who completed study, 34% anemic <120 g/L), 73% had <15.0 μg/L) 48% negative stores (Cook’s algorithm). After days feeding, there was significant group difference change (difference=3.5 g/L, p<.001) (difference=0.45 mg/kg, p=.033) high compared group. Also, 54 109 baseline increased their by 1.5 30% more responders Conclusions Consumption iron‐biofortified over 4.5 months improved Grant Funding Source HarvestPlus/IFPRI