Extraintestinal helminth infection reduces the development of colitis‐associated colorectal cancer (LB518)

• DOI: 10.1096/fasebj.28.1_supplement.lb518
• Publication Date: 2021-06-16T09:41:55Z
• Authors: Luis Terrazas; Blanca Callejas; Sonia León‐Cabrera; Carlos Perez‐Plas...; Emma Bertha Gutié...; Yolanda Chirino; Yadira Ledesma‐Soto; Federico Avila‐Mo...; Miriam Rodriguez‐...
• Keywords: Taenia crassiceps

Whereas a causal association between viral and bacterial infections with tumor development has been well established in animal epidemiological studies, the impact of parasitic cancer is almost unknown. Evidences indicate that can be triggered by chronic or deregulated inflammatory processes, such as colitis‐associated colorectal (CAC). Using helminth infection model, we have analyzed role helminth‐induced anti‐inflammatory response determining outcome CAC. Following Taenia crassiceps CAC, mice displayed inhibited colonic responses reduced circulating CD11b+Ly6C+CCR2+ monocytes. Instead they increased expression IL‐4 alternatively activated macrophages (AAMs) markers at tissue. Strikingly, T. crassiceps‐infected developed few tumors pathology. In contrast, uninfected mounted strong responses, did not express AAMs markers, severe pathology multiple tumors. Thus, immunomodulatory activities induced may resistance progression Grant Funding Source : Supported 167799 CONACYT (Mexico), PAPIIT‐UNAM IN213512, PAPCA‐2013 FES‐Iztacala 16, 19, 28