Nobiletin and atorvastatin synergistically inhibit azoxymethane (AOM)‐induced colon carcinogenesis in rats

• DOI: 10.1096/fasebj.29.1_supplement.271.2
• Publication Date: 2021-06-21T16:50:01Z
• Authors: Xian Wu; Mingyue Song; Zili Gao; Kanyasiri Rakariy...; Jinkai Zheng; Hang Xiao
• Keywords: Nobiletin; Aberrant crypt foci

Accumulating studies have suggested that combination of cancer chemopreventive agents may produce enhanced protective effects against carcinogenesis than each individual agent alone. The efficacy by the can also lower required dose for single in combination, which unwanted side‐effects possibly caused use high agents. Herein, we investigated nobiletin (NBT, a citrus polymethoxyflavone) with atorvastatin (ATST, lipid‐lowering drug) an AOM‐induced colon rat model. results showed oral administration NBT or ATST alone significantly decreased tumor incidence and multiplicity. However, co‐treatment at their half doses produced stronger inhibitory effect on multiplicity comparison to those treatments ATST. Statistical analysis confirmed treatment were synergistic. Immunoblotting had much anti‐proliferative pro‐apoptotic colonic tissue, was evidenced expression levels cyclin D/CDK4 E/CDK2, higher cleaved caspase‐7, leaved caspase‐3, PARP p53 In conclusion, our demonstrated strong synergy inhibiting vivo , provided basis using chemoprevention.