Chemopreventive Effects of Nobiletin on Azoxymethane‐Induced Colon Carcinogenesis in Rats is Associated with Inhibition of Heat Shock Proteins

• DOI: 10.1096/fasebj.29.1_supplement.752.20
• Publication Date: 2021-06-21T16:59:14Z
• Authors: Xian Wu; Mingyue Song; Zili Gao; Jinkai Zheng; Hang Xiao
• Keywords: Nobiletin

Heat shock proteins (HSPs) is a highly conserved family of molecular chaperones that act to facilitate the proper folding multiple proteins, which allows these achieve their functional conformation. HSPs are overexpressed in many human cancers and implicated tumor cell proliferation, differentiation, invasion metastasis. Our results have demonstrated nobiletin (NBT), major citrus flavonoid, can directly bind HSP70 HSP90 colon cancer cells, provide rationale determine role anticancer effects NBT on carcinogenesis. showed oral administration significantly decreased incidence, multiplicity, burden azoxymethane-treated rats. Immunoblotting reduced expression levels both colonic mucosa. Consequently, p53, p21, p27 Bax were increased. The treatment also VEGF, EGFR, cyclin D/CDK4 E/CDK2. Moreover, suppressed COX-2 MMP-9 Overall, our carcinogenesis rats be partially attributed its inhibitory HSPs.