Preventive Effects of American Style Natural Raw Meal (NRM‐A) on Azoxymethane (AOM)/Dextran Sulfate Sodium (DSS)‐Induced Colitis‐Associated Colon Cancer in C57BL/6J Mice

• DOI: 10.1096/fasebj.29.1_supplement.753.7
• Publication Date: 2021-06-21T16:59:14Z
• Authors: Kun‐Young Park; Jia‐Le Song; Sung Ho Shin; Myoung Gyu Park; Sung Joo Hwang
• Keywords: 0303 health sciences; 03 medical and health sciences

The present study was to investigate the effect of American style natural raw meal (NRM-A, JUVO®) which contains high levels freeze-dried brown rice and berries on Azoxymethane (AOM, 10 mg/kg) Dextran Sulfate Sodium (DSS, 2%)-induced colon cancer in C57BL/6J mice. Freeze-dried vegetables enriched Korean (NRM-K), anti-diabetic NRM (NRM-DM) were used as positive controls. Colon length, ratio weight tumor numbers tissue employed evaluate preventive effects NRM-A Histological changes observed by hematoxylin eosin (H&E) staining assay. significantly suppressed AOM/DSS-induced neoplasia, shortening decreased length. observation suggested that effectively neoplasia induced AOM/DSS than those found NRM-K NRM-DM. serum pro-inflammatory cytokines including necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6 IFN-γ, well their mRNA mucosa. also reduced iNOS COX-2 inhibit other samples-treated