Effects of Naringin on hepatic paraoxonase activity and lipid metabolism in type 2 diabetic rats

• DOI: 10.1096/fasebj.30.1_supplement.692.19
• Publication Date: 2023-11-26T16:34:18Z
• Authors: Solomon Oladapo R...; Isaacson B Adelani; Goodness Esther B...; Oluwakemi A Rotimi
• Keywords: Naringin; Paraoxonase; Hepatic lipase

Naringin is one of the citrus‐derived flavonoids that have been reported for its antihyperglycemic, antihyperlipidemic and antioxidant properties. Although usefulness as nutraceutical in management diabetes has reported, there a dearth information on involvement lipid‐associated protein like paraoxonase antidiabetic activity. In order to investigate this, high fat‐low streptozocin model type 2 diabetic rats were treated daily with 50mg/kg, 100mg/kg 200mg/kg naringin orally 21days. The levels plasma insulin dipeptidyl peptidase‐4 (DPP IV) determined using enzyme‐linked immunosorbent assay while other biomarkers T2DM, activity lipid profile assayed spectrophotometrically. expression hepatic 3‐hydroxy‐3‐methyl‐glutaryl‐CoA reductase (HMGCR), scavenger receptor class B member 1 (SCARB1), Aryl Hydrocarbon Receptor (AhR), Lipoprotein Lipase (LIPL), Lecithin—cholesterol acyltransferase (LCAT) assessed reverse transcriptase polymerase chain reaction technique. treatment resulted significant (p<0.05) decrease glucose, insulin, free fatty acid, amylase DPP IV. was also associated cholesterol triglyceride liver dose‐dependent pattern. liver, carnitine palmitoyltransferase significantly increased HMGCR only reduced by 200mg/Kg treatment. Meanwhile, SCARB1, AhR, LIPL LCAT upregulated T2DM activities PON plasma, HDL VLDL, observed liver. These alterations however reversed results showed involved action naringin.