Development of different phenotypes of hypertensive heart failure

• DOI: 10.1097/00004872-200018010-00016
• Publication Date: 2003-04-24T11:28:21Z
• Authors: Reiko Doi; Tohru Masuyama; Kazuhiro Yamamoto; Yasuji Doi; Toshiaki Mano; Yasushi Sakata; Keiko Ono; Tsunehiko Kuzuya; Seiichi Hirota; Toru Koyama; Takeshi Miwa; Masatsugu Hori
• Keywords: Diastolic heart failure

Objective There are two phenotypes of heart failure, systolic failure and isolated diastolic with preserved left ventricular function. Although frequently occurs, there only models for dysfunction unassociated overt have not been established. We attempted to develop different models, i.e. based on hypertension. Materials methods Dahl salt-sensitive rats were placed 8% NaCl diet from 7 weeks old (7-week starting group) or 8 (8-week group). As an age-matched control, consistently normal chow. In these rats, echocardiogram was serially recorded, followed by hemodynamic histological studies. Results The 7-week showed a steep elevation in blood pressure progressive hypertrophy, fell into at approximately 19 weeks. development associated decrease midwall fractional shortening increase end-diastolic dimension as compared the which mimics characteristics clinically observed failure. 8-week gradual rise less 26 mid-wall dimension. Hemodynamic studies failing stage revealed comparable fibrosis both groups. Conclusion These may be useful same hypertensive disease, respectively, contribute discrimination mechanisms