A Model for Chronic Nerve Root Compression Studies

• DOI: 10.1097/00007632-199705010-00003
• Publication Date: 2003-04-24T16:47:51Z
• Authors: Michael Cornefjord; Katsuhiko Sato; Kjell Olmarker; Björn Rydevik; Claes Nordborg
• Keywords: Spinal nerve; Lumbar Nerve; Nerve fiber; Nerve compression syndrome; Motor nerve

Study Design. Compression onset rate, anatomic aspects, and morphologic neurophysiologic effects in spinal nerve roots were studied a root compression model pigs. Objectives. To analyze the rate by measuring gradual reduction of inner diameter constrictor, motor conduction velocity electromyography, changes light microscopy, gross vascular anatomy dissection ink injections, respectively, for experimental chronic compression. Summary Background Data. Chronic is recognized to be related back pain syndromes, including sciatica. Various aspects physiologic have been previously models acute irritation, but controlled, graded has not described. Methods. An ameroid constrictor was applied around just cranial dorsal ganglion. The this gradually becomes reduced. After 1 week or 4 weeks, electromyographic measurements performed, tissue samples harvested histologic analyses. pigs' injections. Results. There statistically significant decrease compressed compared with noncompressed after weeks. constrictors induced fiber damage, endoneural hyperemia, bleeding, inflammation at zone. often severe number myelinated fibers Conclusion. A chronic, partial injury using compression-onset presented. This allows induction controlled can used research on basic pathophysiologic mechanisms various interventions development.