[OP.1C.01] HIGH SALT DIET INCREASES AORTIC STIFFNESS AND PRESSURE PULSE AMPLIFICATION IN RAT

• DOI: 10.1097/01.hjh.0000491346.94278.c2
• Publication Date: 2016-08-10T18:18:01Z
• Authors: M. Butlin; K. Connolly; B. Spronck; D. Georgevsky; C. Mceneiry; I. Wilkinson; A. Avolio
• Keywords: Pulse pressure; Phenylephrine

Objective: High salt consumption is associated with increased blood pressure and vascular changes in humans. This association confounded by other lifestyle factors that could equally influence cardiovascular function. study examines effects of high diet on aortic function a controlled animal study. Design method: Sprague-Dawley rats were fed either (8% sodium chloride, n = 6) or normal chow (0.26% 5) from weaning. Body weight (BW), nose-to-rump length, tail-cuff systolic (SBP), water food intake, urine output measured. At 14 to 17 weeks, anaesthetised thoracic abdominal (invasive solid-state catheters) recorded over physiological mean arterial (MAP) range (60 150 mmHg, induced via intra-venous infusion phenylephrine nitroprusside, 30 μg/kg/min). Aortic pulse wave velocity (aPWV) amplification (PPA) calculated. Left ventricular (LV) kidney mass post-mortem. Results Results: had lower BW (average across all age: 451 ± 57 g, control 498 68 p 0.03), body index (0.79 0.08 g/cm2, 0.82 0.10 < 0.001) (kidney/BW 0.50 0.09%, 0.39 0.05%, 0.01) without LV hypertrophy (LV/BW 0.24 0.04%, 0.22 0.03%, 0.16). Food intake was similar (high 20 3 g/day, 19 5 0.36). drank more (65 10 ml/day, 22 6 correspondingly higher (55 9 15 ml/day 0.001); conscious SBP greater (125 12 117 13 0.05). resulted aPWV MAP 60 4.3 0.2 5.4 m/s, 3.6 0.3 3.9 1.1 0.001 at each mmHg interval). PPA 0.78 0.04 1.53 0.27, 0.62 0.14 1.25 0.17, Conclusions: A moderately pressure, stiffness PPA, indicating marked transmission characteristics the aorta, including altered gradient aorta changed peripheral reflection characteristics.