Mirtazapine Treatment of Social Phobia in Women

• DOI: 10.1097/01.jcp.0000186871.04984.8d
• Publication Date: 2005-11-10T09:02:03Z
• Authors: Moritz Muehlbacher; Marius K. Nickel; Cerstin Nickel; Christian Kettler; Claas Lahmann; Francisco Pedrosa...; Peter K. Leiberich; Nadine Rother; Egon Bachler; Reinhold Fartacek; Patrick Kaplan; Karin Tritt; Ferdinand Mitterl...; Javaid Anvar; Wolfhardt K. Rother; Thomas H. Loew; Christoph Egger
• Keywords: Mirtazapine; Phobic disorder

Social phobia is an anxiety disorder characterized by extreme fear and phobic avoidance of social performance situations a relatively poor health-related quality life. The goal this study was to compare the efficacy mirtazapine versus placebo in treatment patients with phobia. In 2004, we conducted randomized, double-blind, placebo-controlled 66 female subjects from general population meeting criteria for were randomly assigned 1:1 manner (n = 33) or 33). lasted 10 weeks. Seven dropped out. Primary outcome measures self-reported changes on Phobia Inventory, Liebowitz Anxiety Scale, Health Survey (SF-36). comparison group according intent-to-treat principle, significant differences Inventory Scale scales (all P < 0.001), as well most (5 8) SF-36 observed mirtazapine-treated subjects. All tolerated well. Mirtazapine appears be effective agent women improvement their