Activation of Nitric Oxide—Cyclic Guanosine Monophosphate Signaling in Kidney by Extracorporeal Shock Wave Therapy

• DOI: 10.1097/01.ju.0000094186.19728.c2
• Publication Date: 2004-08-25T22:33:54Z
• Authors: JONG KWAN PARK; YONG CUI; HYUNG JIN KIM; HEUI KYOUNG OH; GOU YOUNG KOH; KYUNG WOO CHO
• Keywords: Cyclic guanosine monophosphate

No AccessJournal of UrologyINVESTIGATIVE UROLOGY1 Dec 2003Activation Nitric Oxide—Cyclic Guanosine Monophosphate Signaling in Kidney by Extracorporeal Shock Wave Therapy JONG KWAN PARK, YONG CUI, HYUNG JIN KIM, HEUI KYOUNG OH, GOU YOUNG KOH, and KYUNG WOO CHO PARKJONG PARK More articles this author , CUIYONG CUI KIMHYUNG KIM OHHEUI OH KOHGOU KOH CHOKYUNG View All Author Informationhttps://doi.org/10.1097/01.ju.0000094186.19728.c2AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: We defined whether extracorporeal shock wave therapy (ESWT) the kidney activates nitric oxide (NO)-cyclic 3′,5′-guanosine monophosphate (cGMP) pathway. Materials Methods: A total 90 male rabbits were randomly divided into group 1—pretreated with normal saline, 2—pretreated intravenously (IV) Nω nitro-L-arginine-methyl ester (NAME) (100 mg/kg), 3—pretreated IV NAME L-arginine (300 mg/kg) ESWT 1 kidney, 4—pretreated ODQ (1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one) (20 μg/kg) 5—pretreated saline bladder. Plasma nitrite, NO metabolite cGMP analyzed peripheral blood samples before, immediately after, 30 60 minutes after ESWT. Results: but not bladder caused an increase plasma nitrite (186.1 ± 20.6, 217.5 21.6, 241.9 28.4 230.5 25.3 nM) 5 (149.0 14.7, 155.6 18.4, 131.8 13.6 140.0 15.7 nM), (24.2 1.9, 33.8 3.2, 32.9 2.2 29.4 1.9 pmol/ml) (25.5 2.1, 27.5 2.5, 28.7 3.1 25.5 2.6 pmol/ml, respectively). In 2 significantly inhibited production (113.4 18.6, 118.2 19.9, 114.6 18.3 112.5 17.6 (19.4 2.6, 20.6 2.8, 19.3 2.7 18.6 pmol, 3 was recovered L-arginine. 4 production. Conclusions: The results show that increases level released animal model. References : Protective effect verapamil on induced renal tubular dysfunction. J Urol1993; 150: 27. Abstract, Google Scholar Effects lithotripsy levels cyclic nucleotides human subjects. Urol2002; 168: 38. Endothelium-derived relaxing factor, oxide: effects mesangial cells glomerulus. Am Soc Nephrol1993; 3: 1435. Expression synthase macula densa cells. Int1992; 42: 1017. Topography synthesis localizing constitutive synthases mammalian kidney. Physiol1995; 268: F885. 6 kidney: synthesis, localization, function. Dis1994; 24: 112. 7 inflammatory mediator glomerular Nephron1993; 64: 518. 8 Cyclic strain upregulates cultured bovine aortic endothelial Clin Invest1995; 96: 1449. 9 Constitutive NOS expression is elevated fluid shear stress. 269: H550. 10 Renal hypertensive complications lithotripsy: who at risk?. Urol Int1999; 62: 195. 11 nifedipine allopurinol high energy acute changes Urol1995; 153: 596. Link, 12 Regulatory functions vascular endothelium. N Engl Med1990; 323: 13 Endothelial gene regulation forces. In: Mechanical Forces Endothelium. Edited . Amsterdam, Netherlands: Harwood Academic Publishers1999: 127. 14 Relationship between size, injury, impairment lithotripsy. Nephrol1999; 10: 1753. Crossref, Medline, 15 Redistribution flow SWL evaluated Gd-DTPA-enhanced magnetic resonance imaging. Endourol1998; 12: 9. 16 Control flow. Biomech1995; 28: 1515. 17 Parallel renin JGA rat under various stimuli. F793. 18 derived factor controls hemodynamics Nephrol1990; 1: 875. 19 Juxtaglomerular apparatus, oxide, signaling. Advances Nephrology. London: Mosby2000: 95. From Departments Urology (JKP, YC, HJK, HKO) Physiology (KWC), Chonbuk National University Medical School Institute for Sciences Research Clinical Medicine Hospital, Chonju Pohang Science Technology (GYK), Pohang, South Korea© 2003 American Urological Association, Inc.FiguresReferencesRelatedDetails Volume 170Issue 6December 2003Page: 2459-2462 Advertisement Copyright & Permissions© Inc.Keywords5′-guanylic acidlithotripsykidneyrabbitsnitric oxideMetricsAuthor Information Expand PDF downloadLoading ...