MP45-20 THE ASSOCIATION BETWEEN PRESCRIPTION MEDICATIONS AND KIDNEY STONE PREVALENCE AMONG U.S. ADULTS

• DOI: 10.1097/01.ju.0001008764.86460.8e.20
• Publication Date: 2024-04-15T21:36:53Z
• Authors: Frank E. Glover; Kait F. Al; Jeremy P. Burton; Edouard H. Nicaise; Viraj Master; Kenneth Ogan; Albert Ha; Michael Scott; Francesco Del Giu...; Federico Belladelli; Michael L. Eisenberg
• Keywords: Kidney stone disease; Association (psychology)

You have accessJournal of UrologyStone Disease: Epidemiology & Evaluation II (MP45)1 May 2024MP45-20 THE ASSOCIATION BETWEEN PRESCRIPTION MEDICATIONS AND KIDNEY STONE PREVALENCE AMONG U.S. ADULTS Frank E. Glover, Kait F. Al, Jeremy P. Burton, Edouard H. Nicaise, Viraj Master, Kenneth Ogan, Albert Ha, Michael Scott, Francesco Del Giudice, Federico Belladelli, and L. Eisenberg GloverFrank Glover , AlKait Al BurtonJeremy Burton NicaiseEdouard Nicaise MasterViraj Master OganKenneth Ogan HaAlbert Ha ScottMichael Scott GiudiceFrancesco Giudice BelladelliFederico Belladelli EisenbergMichael View All Author Informationhttps://doi.org/10.1097/01.JU.0001008764.86460.8e.20AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION OBJECTIVE: Kidney stone disease (KSD) poses a significant morbidity mortality with an estimated 10% prevalence in the U.S., incidence KSD has increased alongside prescription medication use. Several drug classes (e.g. antibiotics, antivirals, diuretics) previously been associated literature, though results are inconclusive not necessarily evaluated populations. We investigated association between use METHODS: Data was leveraged from 2009-2018 National Health Nutrition Examination Survey (NHANES) survey cycles – nationally representative population-based cross-sectional study men women From in-person interviews, defined by "yes" having ever passed stone, patterns usage were recorded. Confounding potential biological sex, age, race/ethnicity, hydration status, BMI, metabolic syndromes, income, education empirically assessed dataset using "change-in-estimate" method. Multivariable, weighted logistic regression models constructed quantify relationship medications KSD. Sensitivity analyses performed excluding patients receiving antibiotics for UTI, kidney, or bladder health based on ICD-10-CM codes. Final included 7,336 adults, which represents 79,562,476 people weights. RESULTS: Overall, 1,650 (5%) initial respondents had 48% male. The average age participants 48 (IQR: 32-63) compared 45 43-66) non Participants took 5.8 meds average. Nonsignificant trends observed total (OR=0.99, [0.97,1.01]), antibiotic (OR=1.36, 95%CI [0.62,2.96]), diuretic (OR=0.82, [0.45,1.51]). Importantly, detected antiviral (OR=2.42, [1.34,4.36]), recurrent formation (2 more stones) (OR=1.95, [1.29,2.94]). CONCLUSIONS: current report constitutes largest, investigation A identified KSD, important among formers. Future studies warranted corroborate these findings, determine clinical significance, elucidate mechanisms underlying associations. Source Funding: No sources funding disclose © 2024 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e751 Advertisement Copyright Permissions© Inc.Metrics Information More articles this author Expand PDF downloadLoading ...