PD03-06 MITOCHONDRIAL COMPLEX I PROTEIN NDUFS3 IS DECREASED IN BENIGN PROSTATIC HYPERPLASIA PATIENTS TREATED WITH CELECOXIB AND/OR FINASTERIDE

• DOI: 10.1097/01.ju.0001009388.01015.e5.06
• Publication Date: 2024-04-15T21:36:53Z
• Authors: Chandler N. Hudson; Teresa T. Liu; Taro Igarashi; Nathalie El-Khoury; Nnamdi Ihejirika; Kelsey Paxton; Juliann Jaumotte; Rajiv Dhir; Joel B. Nelson; Donald B. DeFranco; William A. Ricke; Naoki Yoshimura; Zhou Wang; Laura E. Pascal
• Keywords: Celecoxib; Pathophysiology

You have accessJournal of UrologyBenign Prostatic Hyperplasia: Basic Research & Pathophysiology (PD03)1 May 2024PD03-06 MITOCHONDRIAL COMPLEX I PROTEIN NDUFS3 IS DECREASED IN BENIGN PROSTATIC HYPERPLASIA PATIENTS TREATED WITH CELECOXIB AND/OR FINASTERIDE Chandler N. Hudson, Teresa T. Liu, Taro Igarashi, Nathalie El-Khoury, Nnamdi Ihejirika, Kelsey Paxton, Juliann Jaumotte, Rajiv Dhir, Joel B. Nelson, Donald DeFranco, William A. Ricke, Naoki Yoshimura, Zhou Wang, and Laura E. Pascal HudsonChandler Hudson , LiuTeresa Liu IgarashiTaro Igarashi El-KhouryNathalie El-Khoury IhejirikaNnamdi Ihejirika PaxtonKelsey Paxton JaumotteJuliann Jaumotte DhirRajiv Dhir NelsonJoel Nelson DeFrancoDonald DeFranco RickeWilliam Ricke YoshimuraNaoki Yoshimura WangZhou Wang PascalLaura View All Author Informationhttps://doi.org/10.1097/01.JU.0001009388.01015.e5.06AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract INTRODUCTION AND OBJECTIVE: Benign prostatic hyperplasia (BPH) is treated with multiple medical therapies surgical options variable outcomes. Some the heterogeneity in treatment efficacy may come from an incomplete understanding their molecular cellular impact. A decline essential mitochondrial protein expression has been observed BPH tissues, suggesting dysfunction be a factor pathogenesis. Both finasteride celecoxib associated toxicity other tissues. The objective this study was determine whether might impact function prostate specifically effects on NDUFS3. METHODS: NDUFS3, E-cadherin inflammatory cell immunostaining were performed simple prostatectomy specimens patients naïve androgen manipulation who and/or for 28 days four-arm, phase II randomized, single-blind clinical trial. staining also conducted murine model male mice. Quantification analyses performed. RESULTS: decreased compared normal adjacent prostate. Patients had significantly however there no change infiltration untreated patients. Mice displayed significant decrease infiltration. CONCLUSIONS: These findings suggest that are tissues but Given recently increased dysfunction, therapeutic targeting exacerbate existing Future development strategies improving improve Source Funding: This work funded part by NIH grants K01 AG059899 NIA TL; U54 DK104310, R01 DK131175, DK127081 NIDDK WAR; DK112079 R56 DK107492 ZW; CAIRIBU Convergence Award LEP NIDDK. project used Pitt Biospecimen Core supported award P30CA047904 © 2024 American Urological Association Education Research, Inc.FiguresReferencesRelatedDetails Volume 211Issue 5SMay 2024Page: e78 Advertisement Copyright Permissions© Inc.Metrics Information More articles author Expand PDF downloadLoading ...