Dynamics of Fat Cell Turnover in Humans

• DOI: 10.1097/01.ogx.0000325910.81966.ac
• Publication Date: 2008-08-20T07:06:50Z
• Authors: Kirsty L. Spalding; Erik Arner; Pål O. Westermark; Samuel Bernard; Bruce A. Buchholz; Olaf Bergmann; Lennart Blomqvist; Johan Hoffstedt; Erik Näslund; Tom Britton; Hernan Concha; Moustapha Hassan; Mikael Rydén; Jonas Frisén; Peter Arner
• Keywords: Adult; 2. Zero hunger; Cell Death; Stem Cells; [MATH.MATH-DS] Mathematics [math]/Dynamical Systems [math.DS]; Cell Count; Body Mass Index; 3. Good health; Adipose Tissue; Weight Loss; [SDV.BC.BC] Life Sciences [q-bio]/Cellular Biology/Subcellular Processes [q-bio.SC]; Adipocytes; Humans; Carbon Radioisotopes; Obesity; Cell Size

In most countries today, obesity is increasing at an almost epidemic rate and creating a considerable public health problem by elevating the risk of cardiovascular disease metabolic disorders such as type 2 diabetes. It possible that, result, life expectancy will begin to decline in developed countries; this would be first occurrence recent history. Factors that influence fat mass adulthood remain incompletely understood, but increased lipid storage predeveloped cells, or adipocytes, accepted major determinant adults. The number cells constant both lean obese adults, even after marked weight loss, suggesting adipocytes set childhood adolescent years. has not been established, however, whether changes adulthood. To clarify dynamics seemingly stable population investigators measured adipocyte turnover analyzing integration 14C derived from nuclear bomb tests into genomic DNA. Approximately 10% were found renew themselves each year all adult ages, independently body index. Early-onset does alter either death nor generation rate. This suggests tight regulation adults with disorder. relatively high early-onset may provide new target for its pharmacological management. key understand, molecular level, feedback mechanisms control turnover.