Novel Lymphography Using Indocyanine Green Dye for Near-Infrared Fluorescence Labeling

• DOI: 10.1097/01.sap.0000250896.42800.a2
• Publication Date: 2007-05-10T08:19:15Z
• Authors: Fusa Ogata; Ryuichi Azuma; Makoto Kikuchi; Isao Koshima; Yuji Morimoto
• Keywords: Indocyanine Green; Fluorescence-lifetime imaging microscopy

Lymphedema is known to be caused by many pathologic conditions; however, its diagnostic and therapeutic strategies remain unestablished. In this study, we investigated the usefulness of a novel lymphographic method based on fluorometric sensing using indocyanine green (ICG) dye for imaging lymphatic vessels rat models. The real-time system enabled visualization superficial with diameter 0.1 mm in 33 frames/second. addition, morphologic changes radiation-induced lymphedema model were detected even at latent stage. These results suggest that technique acceptable as an evaluation system.