Activation of D1 Dopamine Receptors Induces Emergence from Isoflurane General Anesthesia

• DOI: 10.1097/aln.0b013e318278c896
• Publication Date: 2012-12-05T21:15:34Z
• Authors: Norman E. Taylor; Jessica J. Chemali; Emery N. Brown; Ken Solt
• Keywords: Quinpirole

Background: A recent study showed that methylphenidate induces emergence from isoflurane anesthesia.Methylphenidate inhibits dopamine and norepinephrine reuptake transporters.The objective of this was to test the hypothesis selective receptor activation anesthesia.Methods: In adult rats, we tested effects chloro-APB (D1 agonist) quinpirole (D2 on time general anesthesia.We then performed a dose-response for chloro-APBinduced restoration righting during continuous anesthesia.SCH-23390 antagonist) used confirm induced by are specifically mediated D1 receptors.In separate group animals, spectral analysis surface electroencephalogram recordings assess neurophysiologic changes anesthesia.Results: Chloro-APB decreased median 330 50 s.The difference in between saline control (n = 6) 222 s (95% CI: 77-534 s, Mann-Whitney test).This statistically significant (P 0.0082).During anesthesia, dose-dependently restored δ power 4).These were inhibited pretreatment with SCH-23390.Quinpirole did not restore had no effect 4) anesthesia.Conclusions: Activation receptors decreases anesthesia produces behavioral evidence arousal anesthesia.These findings suggest receptor-mediated mechanism is sufficient induce anesthesia.T HE discovery anesthetic-induced immobility primarily spinal cord 1-3 has led growing interest studying anesthetic mechanisms at