A Single-nucleotide Polymorphism in SCN9A May Decrease Postoperative Pain Sensitivity in the General Population

• DOI: 10.1097/aln.0b013e31827dde74
• Publication Date: 2012-12-20T20:13:54Z
• Authors: Guangyou Duan; Guifang Xiang; Xianwei Zhang; Ruimei Yuan; Huiming Zhan; Dongmei Qi
• Keywords: Adult; Male; Pain Threshold; Pain, Postoperative; Pain Insensitivity, Congenital; NAV1.7 Voltage-Gated Sodium Channel; Age Factors; Pain Perception; Middle Aged; Polymerase Chain Reaction; 03 medical and health sciences; Logistic Models; Pancreatectomy; 0302 clinical medicine; Gene Frequency; Monitoring, Intraoperative; Humans; Anesthesia; Female; Analgesia; Aged; Pain Measurement

This study aimed to explore the role of a nonsynonymous single-nucleotide polymorphism, 3312G>T, in SCN9A, which was identified probands with congenital indifference pain, but is also present normal controls, prediction individual baseline pain perception, and postoperative sensitivity general population.Preoperative pressure thresholds tolerance were measured 200 patients undergoing pancreatectomy, analgesic demand recorded. These variables compared according SCN9A 3312G>T alleles. Logistic regression analysis used test preoperative inadequate analgesia.The 3312Tallele 22 individuals, frequency 5.5% (22/200). The average patient-controlled analgesia pressing opioid consumption 3312G significantly higher than those 3312T (2.70 [SD: 0.84] vs. 2.05 0.43], P < 0.001; 100.8 40.7] 74.8 20.8] ml, = 0.006). incidence that carrying (29.2% 4.5%; 0.013). Carrying having threshold predicted lower risk analgesia, an odds ratio 0.10 (95% CI: 0.01 0.76, 0.026) 0.32 0.13 0.82, 0.018), respectively.Patients presented presence similar surgical stimulus, had likelihood developing 3312Gallele.