Clinical Evaluation of a New Multiparameter Neuromonitoring Device: Measurement of Brain Tissue Oxygen, Brain Temperature, and Intracranial Pressure

• DOI: 10.1097/ana.0b013e31818f2eac
• Publication Date: 2009-05-21T13:16:57Z
• Authors: Gerald Huschak; Thomas Hoell; Christian Hohaus; Christian Kern; Yvonne Minkus; Hans-Jörg Meisel
• Keywords: Brain tissue; Lumen (anatomy)

The study presented evaluated the first clinical use of a new multiparameter catheter measuring intracranial pressure (ICP), partial brain tissue oxygen (ptiO2), and temperature (TBr) (Neurovent PTO). To assess validity measured ptiO2 second probe, which represents current golden standard measurement, was implanted (Licox system).Thirty patients with indicated invasive measurement ICP under intensive care unit conditions were included. Using double lumen bolt, simultaneously Licox Neurovent PTO. Ex vivo tests on both probes conducted independently by manufacturer PTO (Raumedic AG, Germany).The average individual mean measurements showed no relevant differences between (19.5+/-7.1) probe (21.7+/-9.5). Twenty-eight out 30 proper functioning over desired monitoring period. Raumedic displayed higher malfunction/handling error frequency (2 device errors, 11 handling errors). A comparison data systems according to Bland Altman possible in 18 acceptable results (mean difference -1.24 mm Hg; limits agreement: -25.1 +22.6 Hg). total 95.2% 96,083 recordings within calculated agreement. after explantation revealed stable TBr function probe. Precision Zero did not differ probes, whereas precision 150 Hg greater probes.Combining 3 different neuromonitoring functions 1 might ease making (ptiO2) unnecessary. Interpretation our is limited several factors: (1) monocentric study; (2) reduced mechanical stability, difficulties bolt; (3) design changes improve stability will require further (4) conflict interest because its support for study. conclusion drawn from that does measure ICP, TBr, ptiO2. But all initial given this paper have be interpreted cautiously. necessary when has been improved.