Vancomycin-supplemented Cancellous Bone Allografts in Hip Revision Surgery

• DOI: 10.1097/blo.0b013e318073c290
• Publication Date: 2007-05-11T08:11:42Z
• Authors: Martin Buttaro; Fernando Comba; Francisco Piccaluga
• Keywords: Cancellous bone; Nephrotoxicity; Histology

We explored the role of vancomycin-supplemented cancellous bone allografts in hip revision surgery. evaluated incorporation these 18 pigs' radiographs, histology, and immunohistochemistry. High-quality histologic examination, immunologic expression metalloproteinase-13 transforming growth factor-beta 2 indicated vancomycin did not considerably affect graft incorporation. Elution, bioactivity, nephrotoxicity were subsequently tested 20 patients who underwent reconstruction with this method. Local active bactericidal levels reached 1400.5 microg/mL (average 5-point level, 367.19 microg/mL). Vancomycin was present urine until day 15 without any sign nephrotoxicity. Clinical analysis performed 30 whose hips allograft. At a minimum 2-year followup, infection control attained 29 (reinfection rate, 3.3%; 95% confidence interval, 0.08-17%) evidence resorption. Histologic observations two reconstructed technique similar to ones reported nonsupplemented allografts. Our findings encourage continued use reconstructive orthopaedic