Increased mortality in long-term intensive care patients with active cytomegalovirus infection*

• DOI: 10.1097/ccm.0b013e31818f3fc4
• Publication Date: 2008-11-12T08:22:57Z
• Authors: Malte Ziemann; Beate Sedemund-Adib; Petra Reiland; Peter Schmucker; Holger Hennig
• Keywords: Cytomegalovirus; Betaherpesvirinae

To determine the prevalence and impact on patient outcome of active human cytomegalovirus infections in patients with prolonged treatment an intensive care unit.Retrospective analysis stored plasma samples.Anesthesiological unit a university hospital.All 138 treated for at least 14 days (of total 4940 admitted during study period). Immunocompromised inconclusive results DNA were excluded.None.Stored samples stay tested DNA. Sixty-four 255 evaluable from 99 immunocompetent DNA-positive mean concentration 8,600 genome equivalents per milliliter. Active infection was diagnosed by reproducibly positive 35 (35%). Only one case had been clinically. Patients without not significantly different parameters, such as age, sex, admission category, source admission, or comorbidities. Even review specific surgical procedures use heart-lung-machine showed no significant differences between groups. The mortality rate increased (28.6% vs. 10.9%, p = 0.048), surviving longer (32.6 22.1 days, <0.001).Active is frequent but seldom finding stay, which associated patients.