Pentastarch 10% (250 kDa/0.45) is an independent risk factor of acute kidney injury following cardiac surgery*

• DOI: 10.1097/ccm.0b013e31819cc1a0
• Publication Date: 2009-05-21T16:29:57Z
• Authors: Jean-Philippe Rioux; Myriam Lessard; Bruno De Bortoli; Patrick Roy; Martin Albert; Colin Verdant; François Madore; Stéphan Troyanov
• Keywords: Male; Plasma Substitutes; Acute Kidney Injury; 3. Good health; Hydroxyethyl Starch Derivatives; 03 medical and health sciences; Postoperative Complications; 0302 clinical medicine; Risk Factors; Humans; Female; Cardiac Surgical Procedures; Aged; Retrospective Studies

Objective, Design and Patients: The risk of acute kidney injury (AKI) associated with hydroxyethyl starch may be limited to higher molecular weight agents. We retrospectively evaluated the AKI using pentastarch 10% (250 kDa, 0.45) in a random cohort 563 patients operated for cardiac surgery at university hospital. Measures: assessed previously identified preoperative, perioperative, postoperative factors, volume given until end first day. defined by 50% rise serum creatinine within 4 days after surgery. Different propensity adjustment methods were used further assess selection bias. Results: Fifty-four (10%) developed AKI. Risk factors age, female gender, preoperative clearance, hypertension, diuretic use, left ventricular ejection fraction, valvular surgery, duration extracorporeal circulation, dose vasopressor support, number red blood cells fresh frozen plasma transfusions. Patients received 16 ± 9 mL/kg as opposed 10 7 controls (p < 0.001). Pentastarch remained independently predictive AKI, an adjusted odds ratio per 1.08 (95% confidence interval 1.04–1.12, p = This was dose-dependent, optimal cutoff predicting 14 mL/kg. tested, factor identified. Conclusions: study dose-dependent following