Morphologic and functional renal impact of acute kidney injury after prolonged hemorrhagic shock in mice*

• DOI: 10.1097/ccm.0b013e31821f04f0
• Publication Date: 2011-05-13T09:07:21Z
• Authors: Nicolas Mayeur; Vincent Minville; Acil Jaafar; Julien Allard; Talal al Saati; Céline Guilbeau-F...; Olivier Fourcade; Jean Pierre Girolami; Stéphane Schaak; Ivan Tack
• Keywords: Renal medulla; Acute tubular necrosis

Sparse data are available on renal consequences of hemorrhagic shock in mice. This study aimed to extend the current knowledge functional and morphologic impact mice determine its ability stand as an accurate model acute kidney injury.In vivo study.University research unit.C57/Bl6 mice.A controlled was adapted mice.Renal functions morphology were followed up from 3 hrs 21 days after shock. When prolonged 2 hrs, hypotension (35 mm Hg mean arterial blood pressure) induced by temporary removal responsible for early lasting increase hypoxia-inducible factor-1α kidney-inducible molecule-1 gene expression that paralleled tubular necrosis failure. Two-hr important but reversible decrease glomerular filtration rate 6 Other dysfunctions included a loss sodium, assessed sodium excretion, urine concentration persists day 21. Tissular damages prevailed outer medulla shock, being maximal at 6. At 21, healing associated with epithelial recovery significant interstitial fibrosis.Our indicate apparent function injury can mask persisting tissular could predispose chronic disease. Prolonged closely mimics effects similar situation humans, thus providing useful tool investigate pathophysiological mechanisms protection strategies against situations such