Noninvasive versus invasive ventilation for acute respiratory failure in patients with hematologic malignancies: A 5-year multicenter observational survey*

• DOI: 10.1097/ccm.0b013e3182227a27
• Publication Date: 2011-06-10T11:57:15Z
• Authors: Giuseppe R. Gristina; Massimo Antonelli; Giorgio Conti; Alessia Ciarlone; Silvia Rogante; Carlotta Rossi; Guido Bertolini
• Keywords: Acute respiratory failure; Noninvasive Ventilation

Mortality is high among patients with hematologic malignancies admitted to intensive care units for acute respiratory failure. Early noninvasive mechanical ventilation seems improve outcomes.To characterize use in Italian failure and its impact on outcomes vs. invasive ventilation.Retrospective analysis of observational data prospectively collected 2002-2006 1,302 158 units.Mortality (intensive unit hospital) was assessed treated initially those ab initio after Findings were adjusted propensity scores reflecting the probability initial treatment ventilation.Few (21%) received ventilation; 46% these later required ventilation. Better associated successful (vs. failure), particularly lung injury/adult distress syndrome (mortality: 42% 69% 77%, respectively). Delayed immediate slightly but not significantly higher hospital mortality (65% 58%, p=.12). After propensity-score adjustment, lower than ventilation.The population could be stratified according specific diagnoses. Furthermore, study observational, groups may have included unaccounted differences covariates although risk this bias minimized score regression adjustment.In malignancies, should probably managed Further needed determine whether might offer some benefits syndrome.