Comparison of SpO2 to PaO2 based markers of lung disease severity for children with acute lung injury*

• DOI: 10.1097/ccm.0b013e31823bc61b
• Publication Date: 2012-01-04T16:21:54Z
• Authors: Robinder G. Khemani; Neal J. Thomas; Vani Venkatachalam; Jason P. Scimeme; Ty Berutti; James B. Schneider; Patrick A. Ross; Douglas F. Willson; Mark W. Hall; Christopher J. L....
• Keywords: Pulse Oximetry; Mean airway pressure; Oxygenation index; Arterial blood; Oxygen Saturation

Objective: Given pulse oximetry is increasingly substituting for arterial blood gas monitoring, noninvasive surrogate markers lung disease severity are needed to stratify pediatric risk. We sought validate prospectively the comparability of SpO2/Fio2 PaO2/Fio2 and oxygen saturation index oxygenation in children. also derive a injury score. Design: Prospective, multicentered observational study six intensive care units. Patients: One hundred thirty-seven mechanically ventilated children with SpO2 80% 97% an indwelling catheter. Interventions: Simultaneous gas, oximetry, ventilator settings were collected. Derivation validation data sets generated, linear mixed modeling was used predictive equations. Model performance fit evaluated using set. Measurements Main Results: thousand one ninety SpO2, from 137 patients included. Oxygen had strong association both derivation sets, given by equation = 2.76 1 0.547*oxygenation (derivation). 1/SpO2/Fio2 1/PaO2/Fio2 0.00232 0.443/PaO2/Fio2 criteria acute respiratory distress syndrome 221 (95% confidence interval 215–226) 264 259–269). Multivariate models demonstrated that index, serum pH, Paco2 associated (p < .05); 1/PaO2/Fio2, mean airway pressure, .05). There concordance between derived score original modification difference 20.0361 α0.264 sd. Conclusions: Lung markers, which use adequate those PaO2 failure 97%. They should be clinical practice characterize risk, increase enrollment trials, determine prevalence. (Crit Care Med 2012; 40:–1316)