Neuropsychologic Function Three to Six Months Following Admission to the PICU With Meningoencephalitis, Sepsis, and Other Disorders

• DOI: 10.1097/ccm.0b013e318275d032
• Publication Date: 2013-02-05T13:35:21Z
• Authors: Lorraine C. Als; Simon Nadel; Mehrengise Cooper; Christine M. Pierce; Barbara J. Sahakian; M. Elena Garralda
• Keywords: Interquartile range; Illness severity

To assess short-term neuropsychological function and academic performance in school children following admission to intensive care explore the role of critical neurologic systemic infection.A prospective observational case-control study.Two PICUs.A consecutive sample 88 aged 5-16 years (median age=10.00, interquartile range=6.00-13.00) who were admitted between 2007 2010 with meningoencephalitis, septic illness, or other illnesses. They assessed 3 6 months discharge, their was compared that 100 healthy controls. Patients without prior neurodevelopmental disorder.None.Data encompassing demographic illness details obtained, using tests intellectual function, memory, attention. Questionnaires addressing returned by teachers. After adjusting for covariates, PICUs significantly underperformed on measures comparison controls (p<0.02). Teachers deemed more than as performing educationally worse having problems work (ps=0.001), well below average aspects executive attention (ps<0.04). Analysis effect type outcome revealed such memory teacher-rated most reduced meningoencephalitis illness. In PICU group, multivariable linear regression a composite score neuropsychologic impairment prevalent when younger, from lower social class, had experienced seizures during (ps<0.02).Admission is followed deficits educational difficulties, severe difficulties noted These results highlight importance future studies cognition incorporating moderating factor.