DUSP10 gene polymorphism and risk of colorectal cancer in the Han Chinese population

• DOI: 10.1097/cej.0b013e3283647408
• Publication Date: 2013-07-19T10:41:04Z
• Authors: Tao Zhang; Xiaolan Li; Qingguo Du; Sangmingjiu Gong; Min Wu; Zhijun Mao; Zengzhan Gao; Yanbin Long; Tianbo Jin; Tingting Geng; Jianhua Wang; Chao Chen
• Keywords: Linkage Disequilibrium

Dual-specificity protein phosphatases (DUSP) negatively regulate members of the mitogen-activated kinase superfamily, which is associated with cellular proliferation and differentiation. A recent study suggests that DUSP10 frequently upregulated in colorectal cancer (CRC). Our aimed to assess whether contributes risk CRC. We analyzed nine tag single nucleotide polymorphisms (tSNPs) a case–control Han Chinese by χ2-test SHEsis software. found two tSNPs (rs908858, P=0.00004; rs11118838, P=0.02510) were significantly CRC using χ2-test. Using software, six (rs12041033, rs17010629, rs12724393, rs12036163, rs12044821) same linkage disequilibrium block. Within this block, haplotype 'CTCAAC' showed an increased 42%. By global analysis, we 'ACTCAACTA' may increase ∼53%; 'GCCCACCCA' decrease ∼46%. results, combined previous studies, suggest certain mutations correlate incidence Thus, function gene product contribute toward population.