Value of micromorphometric criteria of sentinel lymph node metastases in predicting further nonsentinel lymph node metastases in patients with melanoma

• DOI: 10.1097/cmr.0b013e328343ecf4
• Publication Date: 2011-02-12T15:36:11Z
• Authors: Astrid Maria Fink; Felix Weihsengruber; Nikolaus Duschek; Michael Schierl; Hannes Wondratsch; Wolfgang Jurecka; Klemens Rappersbe...; Andreas Steiner
• Keywords: Value (mathematics)

Patients with metastases in the sentinel node (SN) are advised to undergo complete lymph dissection, although majority of them will have no further metastatic disease. Some these patients unnecessary surgery. In this study, we tried predict likelihood non-SN on basis earlier published micromorphometric classifications SN metastases. Metastases were re-evaluated microanatomic location lesions according Dewar's criteria, S-classification SN, and tumor burden accordance Rotterdam criteria. The results correlated presence Specimens 124 positive-SN basins subsequent dissection investigated. Further non-SNs found 30 (24.2%). All above-mentioned classification systems significantly status. Especially, subcapsular location, a maximum depth invasion less than 0.3 mm (stage I S-classification) or 0.1 diameter had very low probability (0-5%). validity metastases-based criteria predicting status was confirmed. metastases, SI stage risk