A large retrospective multicenter study of vaginal melanomas

• DOI: 10.1097/cmr.0b013e32835e590e
• Publication Date: 2013-01-22T08:06:17Z
• Authors: Charlotte Vaysse; Patricia Pautier; Thomas Filleron; Veronique Maisong...; Jean-François Rodier; Vincent Lavoue; Fabien Reyal; Laurence Thomas; Arnaud de la Fouc...; Martine Delannes
• Keywords: Adjuvant Therapy; Distant metastasis

The outcome of patients presenting with vaginal melanoma has been assessed in a large multicentric retrospective study. databases 12 French institutions were searched for primary melanomas managed between 1990 and 2007. Among the 54 recorded, 46 curative intent included clinical characteristics, treatments, detection c-KIT protein expression have studied. median age was 63.5 years (42–88). Twenty-eight classified as International Federation Gynecology Obstetrics (FIGO) stage I, five II, six III, one IVA. overexpressed 80% patients. Forty-two underwent surgical resection tumor, nine received local adjuvant treatment, 10 systemic therapy. relapse-free survival 10.9 months. c-KIT-negative status (P=0.01) I (P=0.02) associated locoregional recurrence. rate metastasis increased advanced FIGO stages (P<0.01). overall (OS) 28.4 finding lymph node adversely affected OS Conservative surgery radiotherapy decrease metastasis-free (P<0.01) compared alone, this group (P=0.02). Despite use limited data, conservative combined sentinel procedure, followed by could be proposed to early absence validated management. negativity immunochemistry appears poor prognosis marker terms recurrences but not metastatic spread nor survival. Further assessment role disease is thus mandatory select targeted