Chronic Inflammatory Demyelinating Polyneuropathy and Respiratory Failure Due to Phrenic Nerve Involvement

• DOI: 10.1097/cnd.0b013e3181d80bdc
• Publication Date: 2010-08-28T11:03:52Z
• Authors: Cengiz Tataroglu; Ayca Ozkul; Ahmet Sair
• Keywords: Phrenic nerve; Diaphragm (acoustics); Polyradiculoneuropathy

In this article, 2 patients with chronic inflammatory demyelinating polyneuropathy (CIDP) are presented. These developed respiratory failure which could not be explained by any cardiac or pulmonary pathology. The first case had pure motor involvement and probable CIDP, the second severe sensorial dysfunction an ataxic picture in addition to symptoms. His clinical was compatible distal acquired sensory neuropathy without M protein. Electrophysiologic investigations of both disclosed impaired phrenic nerve conduction neurogenic unit changes diaphragm. Both showed a moderate response immunotherapy. Distal variant CIDP can cause dysfunction. Different patterns should evaluated for involvement.