Clinical Significance of ABCG2 Haplotype-tagging Single Nucleotide Polymorphisms in Patients With Unresectable Non–Small Cell Lung Cancer Treated With First-line Platinum-based Chemotherapy

• DOI: 10.1097/coc.0b013e318297f333
• Publication Date: 2013-05-18T11:51:53Z
• Authors: Seok-Hyun Kim; Moon Jin Kim; Yu Ji Cho; Yi Yeong Jeong; Ho-Cheol Kim; Jong Duk Lee; Young Sil Hwang; In-Suk Kim; Suee Lee; Sung Yong Oh; Hui Ling; Gyeong-Won Lee
• Keywords: Taxane

Objectives: The ATP-binding cassette (ABC) ABCG2, involved in multidrug resistance (MDR) cancer cells, plays an integral role drug resistance. Single nucleotide polymorphisms (SNPs) have been identified many MDR-associated ABC genes that seem to influence sensitivity/resistance through various mechanisms. Therefore, we investigated whether ABCG2 haplotype-tagging SNPs (htSNPs) were associated with clinical outcomes patients unresectable non–small cell lung (NSCLC) treated front-line platinum-based chemotherapy. Patients and Methods: We genotyped 4 htSNPs for 129 NSCLC cases first-line Clinical characteristics, treatment outcomes, predictive value of the patient response, survival, adverse events related chemotherapy analyzed according each htSNP using χ2 test, Kaplan-Meier method, Cox proportional hazard model. Results: rs2725264 was significantly overall survival (OS) (P=0.018, log-rank test). median duration (in months) T/T, T/C, C/C genotypes 35.75 (95% confidence interval [CI], 24.25-47.25), 34.25 (hazard ratio [HR] 1.27 [0.68 2.35]; 95% CI, 27.16-41.34), 14.89 (HR 3.22 [1.26 8.24], 13.86-15.92), respectively. as independent factor by model analysis (P=0.028). In taxane-based groups, OS (P=0.041), whereas gemcitabine-based rs4148149 (P=0.014). Conclusions: Our data suggest (overall group taxane-platinum combination group) (gemcitabine-platinum Thus, may be independently