Lupus Erythematosus Panniculitis: Clinicopathological, Immunophenotypic, and Molecular Studies

• DOI: 10.1097/dad.0b013e3181b4a5ec
• Publication Date: 2010-01-20T05:28:48Z
• Authors: Hyun Sun Park; Jung Won Choi; Byoung-kwon Kim; Kwang Hyun Cho
• Keywords: Panniculitis; Histopathology; Immunophenotyping; Fat necrosis

Lupus erythematosus panniculitis (LEP) is an inflammatory disorder of the subcutaneous fat in patients with lupus (LE). It a rare variant disease, which occurs approximately 1%-3% cutaneous LE. The purpose this study was to investigate clinical, histopathologic, immunophenotypical, and molecular profiles LEP. We performed retrospective 19 biopsy specimens from 17 reviewed their clinical data reexamined histopathology. Immunophenotyping studies were done using sections paraffin-embedded formalin-fixed tissue. most common manifestation depressed patch on upper arm. Patients showed good response variable treatment modalities, but, generally, relapse noted when discontinued. Histopathologically, revealed lymphoplasmacytic lobular epidermal dermal changes LE, hyaline necrosis, lymphoid follicles. Immunohistochemistry mixture T B cells dermis subcutis slight preponderance cell. Although polymerase chain reaction analysis T-cell receptor-γ gene rearrangement polyclonal smear 89.5% cases, small portion demonstrated monoclonality. LEP chronic recurrent disease characteristic features. Its diagnosis often challenging, precise achievable only upon elaborate clinicopathologic correlation integrated interpretation all diagnostic criteria.