Prenatal and Perinatal Morbidity in Children with Tourette Syndrome and Attention-Deficit Hyperactivity Disorder

• DOI: 10.1097/dbp.0b013e31819e6a33
• Publication Date: 2009-05-21T12:59:13Z
• Authors: Tamara Pringsheim; Paul Sandor; Anthony Lang; Prakeshkumar Shah; Paul O'Connor
• Keywords: Male; Smoking; Infant, Newborn; Mothers; Environmental Exposure; Infant, Low Birth Weight; Respiration Disorders; 3. Good health; 03 medical and health sciences; Logistic Models; 0302 clinical medicine; Attention Deficit Disorder with Hyperactivity; Pregnancy; Case-Control Studies; Prenatal Exposure Delayed Effects; Multivariate Analysis; Odds Ratio; Birth Weight; Humans; Premature Birth; Female; Morbidity; Child

Tourette syndrome (TS) and attention-deficit hyperactivity disorder (ADHD) are frequently seen in combination, though the cause of comorbidity is uncertain. Low birth weight a known risk factor for ADHD. The objective study was to assess association between pre- perinatal morbidity comorbid diagnosis ADHD children with TS.A nested case-control evaluated TS at subspecialty clinic performed. Cases were defined as ADHD; controls had without Exposure assessed using demographic information booklets completed by parents before diagnostic interview.Three hundred fifty-three included, 181 cases 172 controls. Children greater odds exposure low status, prematurity, breathing problems, maternal smoking compared only. A multivariable logistic regression model found adjusted ratios 2.74 (95% CI 1.03-7.29, p = .04) born weight, 2.43 1.23-4.82, .01) exposed smoking.In TS, there or smoking. commonality factors only tic-related supports common underlying neurobiology. Women fetuses should avoid preventable causes minimize