Population Pharmacokinetics of Piperacillin Using Scavenged Samples From Preterm Infants

• DOI: 10.1097/ftd.0b013e3182587665
• Publication Date: 2012-05-08T11:42:32Z
• Authors: Michael Cohen-Wol...; Daniel K. Benjamin; Ashley Ross; Laura P. James; Janice E. Sullivan; Michele C. Walsh; Arlene Zadell; Nancy Newman; Nicole R. White; Angela D. M. Kashuba; Daniele Ouellet
• Keywords: Male; Piperacillin; 0301 basic medicine; Blood Specimen Collection; Infant, Newborn; Gestational Age; Anti-Bacterial Agents; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Models, Chemical; Humans; Computer Simulation; Female; Prospective Studies; Infant, Premature

Piperacillin is often used in preterm infants for intra-abdominal infections; however, dosing has been derived from small single-center studies excluding extremely preterm infants at highest risk for these infections. We evaluated the population pharmacokinetics (PK) of piperacillin using targeted sparse sampling and scavenged samples obtained from preterm infants ≤32 weeks gestational age at birth and <120 postnatal days.