Protective effect of Sideritis euboea extract on bone mineral density and strength of ovariectomized rats

• DOI: 10.1097/gme.0b013e31820ce580
• Publication Date: 2011-04-19T10:02:50Z
• Authors: Ismene A. Dontas; Pavlos P. Lelovas; Stavros K. Kourko...; Nektarios Aligiannis; Anna Paliogianni; Sofia Mitakou; Antony Galanos; Eva Kassi; Athanasios Mitous...; Theodore T. Xanthos; Nikolaos Papaioannou; George P. Lyritis
• Keywords: 0303 health sciences; Compressive Strength; Plant Extracts; Ovariectomy; Biomechanical Phenomena; Rats; 3. Good health; Disease Models, Animal; Random Allocation; 03 medical and health sciences; Bone Density; Animals; Humans; Osteoporosis; Sideritis; Rats, Wistar; Phytotherapy

In Brief Objective: The aim of this study was to investigate the potential protective effect Sideritis euboea extract (SID), commonly consumed as "mountain tea," on bone mineral density (BMD) and strength ovariectomized (OVX) rat model osteoporosis. Methods: Thirty-two 10-month-old Wistar rats were separated into controls (sham operated), OVX, OVX plus SID in their drinking water (dose, 330 mg/kg body weight per day), starting immediately after for 6 months. Tibial BMD at baseline 3 months post-OVX, three-point-bending femur, uterine end examined. Results: percentage change from whole tibia similar control + (−3.02% vs −4.67%, P = not significant), revealing a strong osteoprotective effect. At months, corresponding changes −6.02% versus −14.37%, < 0.05, indicating greater loss treated rats, albeit significantly less than (−20.46%; SID, 0.05). proximal (metaphyseal) tibial between groups (−26.47% −15.57% −31.22% −16.57%, respectively) statistically significant, demonstrating that preserved group significantly. Three-point-bending showed significant increase compared with groups. Body weights Conclusions: protected improved femoral biomechanical rats. plant euboea, by population mountain tea, examined mature It demonstrated nontreated animals, without having an weight.