Appendicular fat mass is positively associated with femoral neck bone mineral density in older women

• DOI: 10.1097/gme.0b013e31822a8d51
• Publication Date: 2011-10-25T08:13:54Z
• Authors: Elisa A. Marques; Pedro Moreira; Flávia Wanderley; Andreia N. Pizarro; José P. Leão-Rosas; Jorge Mota; Joana Carvalho
• Keywords: Appendicular skeleton

In this study, we examined the relationships between body fat accumulation and distribution bone mineral density (BMD) in older women.A total of 100 healthy white women (mean ± SD age, 68.7 5.5 y) free medications known to affect were enrolled. Lean mass, mass (FM), percentage fat, android FM, gynoid appendicular FM (AFM), lean femoral neck BMD measured by dual-energy x-ray absorptiometry. Dietary intake was assessed 4-day dietary record, potential renal acid load also calculated. Performance measures included knee extension flexion strength on an isokinetic dynamometer. Physical activity using accelerometers a questionnaire. Lactase nonpersistence defined C/T-13910 genotype. Sociodemographic information, lifestyle behaviors, clinical status examined. Stepwise multiple linear regression analysis showed that AFM most significant positive predictor BMD.After adjustment for confounders (age, height, age at menopause, load, physical activity, muscle strength), had strong independent associations with (26.4% variance).These data highlight women, localization is more important than obesity per se or mass. (subcutaneous adiposity) seems exhibit protective effect BMD.