Pulse pressure is an independent determinant of renal function decline during treatment of essential hypertension

• DOI: 10.1097/hjh.0b013e3281fbd15e
• Publication Date: 2007-08-06T07:01:27Z
• Authors: Pierre Fesler; Michel E Safar; Guilhem du Cailar; Jean Ribstein; Albert Mimran
• Keywords: Pulse pressure; Essential hypertension

In large epidemiological studies and using serum creatinine or estimates of glomerular filtration rate (GFR), blood pressure has emerged as a predominant determinant the age-associated decline in renal function.The present longitudinal study (median follow-up period 5.8 years) was conducted 132 never-treated patients with essential hypertension at baseline. The effect treatment on GFR effective plasma flow, estimated by urinary clearances isotopic markers, assessed.Satisfactory control (<140/90 mmHg) achieved 57% population. During follow-up, yearly change -1.72+/-0.21 ml/min per year (mean+/-SEM). univariate regression analysis, correlated baseline pulse (r=-0.27, P=0.002), whereas no influence systolic, diastolic mean pressures, well albuminuria left ventricular mass index, found. Multivariate logistic analysis showed that only conveyed significant odds ratio accelerated (>median 1.5 year), independently age, GFR, other known cardiovascular risk factors. No type antihypertensive (64% population had received angiotensin-converting enzyme inhibitor) detected.Pulse (a marker arterial stiffening) is suggested an independent treatment-associated function hypertension. target organ damage (albuminuria hypertrophy) detected.