Continuous positive airway pressure treatment in sleep apnea patients with resistant hypertension: a randomized, controlled trial

• DOI: 10.1097/hjh.0b013e32833b9c63
• Publication Date: 2010-06-24T09:47:18Z
• Authors: Lourdes Lozano; José Luis Tovar; Gabriel Sampol; Odile Romero; María José Jurado; Alfons Segarra; Eugènia Espinel; José Ríos; María Dolores Unt...; Patrícia Lloberes
• Keywords: Positive airway pressure

Objectives This controlled trial assessed the effect of continuous positive airway pressure (CPAP) on blood (BP) in patients with obstructive sleep apnea (OSA) and resistant hypertension (RH). Methods We evaluated 96 hypertension, defined as clinic BP at least 140/90 mmHg despite treatment three drugs adequate doses, including a diuretic. Patients underwent polysomnography 24-h ambulatory monitoring (ABPM). They were classified consulting room or ABPM-confirmed according to lower higher than 125/80 mmHg. an apnea-hypopnea index 15 events/h (n = 75) randomized receive either CPAP added conventional 38) medical alone 37). ABPM was repeated 3 months. The main outcome change systolic diastolic BP. Results Sixty-four completed follow-up. treated 20), unlike those 21), showed decrease (−4.9 ± 6.4 vs. 0.1 7.3 mmHg, P 0.027). who used > 5.8 h greater reduction daytime {−6.12 [confidence interval (CI) −1.45; −10.82], 0.004}, (−6.98 [CI −1.86; −12.1], 0.009) (−9.71 −0.20; −19.22], 0.046). number dipping pattern significantly increased group (51.7% 24.1%, 0.008). Conclusion In OSA, for months achieves reductions is seen use more h.