Association between serum uric acid, hypertension, vascular stiffness and subclinical atherosclerosis

• DOI: 10.1097/hjh.0b013e328365b916
• Publication Date: 2013-12-05T14:57:35Z
• Authors: Arrigo F.G. Cicero; Paolo Salvi; Sergio D’Addato; Martina Rosticci; Claudio Borghi
• Keywords: Quartile; Subclinical infection; Microalbuminuria

Serum uric acid (SUA) levels correlate with many recognized cardiovascular risk factors, including age, male sex, hypertension, diabetes mellitus, hypertriglyceridemia, obesity, and insulin resistance. The aim of our study was to verify in a large well characterized population sample the relationship between SUA values, arterial stiffness subclinical atherosclerosis.For this study, we selected 248 men 371 women adult patients enrolled last Brisighella Heart Study survey for which full set data were available not consuming antihypertensive, antidiabetic, lipid-lowering acid-lowering drugs. other variables related blood pressure level, carotid-femoral pulse wave velocity (cfPWV) carotid intima-media thickness (cIMT).Hypertension prevalence strongly quartiles: found significant differences 2nd (23.0%) 3rd quartiles (36.4%; P vs. < 0.05), 4th quartile (56.3%; 0.05). Similarly, metabolic syndrome increased significantly at 39.5% (P 0.05 2nd) 58.9% 3rd). Intima-media gradually rose along trend 0.0001), particular, it 0.86 mm 1st quartile, 0.90 2nd, 0.94 3rd, 0.97 each (all In multivariate regression analyses, resulted be associated hypertension prevalence, IMT. Even if association cfPWV univariate analysis = 0.002), when adjusting became nonsignificant (0.20).In studied sample, after adjustment number parameters, appears correlated IMT, but aortic stiffness.