Independent and additive prognostic ability of serum carboxy-terminal telopeptide of collagen type-I in heart failure patients: a multi-marker approach with high-negative predictive value to rule out long-term adverse events

• DOI: 10.1097/hjr.0b013e32833ace76
• Publication Date: 2010-05-14T07:46:36Z
• Authors: D. N. Tziakas; G. K. Chalikias; D. Stakos; S. V. Chatzikyriakou; D. Papazoglou; K. Mitrousi; A. Lantzouraki; A. Thomaidi; H. Boudoulas; S. Konstantinides
• Keywords: Heart Failure; Male; Chi-Square Distribution; Greece; Myocardium; Kaplan-Meier Estimate; Middle Aged; Fibrosis; Collagen Type I; Disease-Free Survival; Peptide Fragments; 3. Good health; 03 medical and health sciences; 0302 clinical medicine; Predictive Value of Tests; Chronic Disease; Natriuretic Peptide, Brain; Disease Progression; Humans; Female; Peptides; Biomarkers; Aged

Altered myocardial extracellular matrix turnover has been proposed as a major determinant of myocardial remodelling. Carboxy-terminal telopeptide of collagen type-I (CITP) represents a collagen type-I degradation-derived serum peptide. In this study we examined the independent and additive prognostic value of serum concentrations of CITP compared with well-known mortality predictors such as the N-terminal pro-brain natriuretic peptide (NT-proBNP) in chronic heart failure (CHF) patients.We studied 196 consecutive patients (126 male, mean age 69 ± 10 years), who were admitted for acute decompensation of the CHF syndrome. The study entry point was determined at the discharge of the patients after achieving a stable compensated status. The primary endpoint was cardiac mortality during a 12-month follow-up.In the multivariate Cox proportional hazard model the levels of CITP remained a predictor of survival (hazards ratio 0.4 95% confidence interval 0.21-0.76, P = 0.005), independent of NT-proBNP levels. The stratified log-rank test (P < 0.001) showed that CHF patients characterized by low levels of both biomarkers had better survival (hazards ratio 0.12 95% confidence interval 0.04-0.35, P < 0.001) compared with patients characterized by high levels of both biomarkers. The negative predictive value of the combined measure for long-term adverse events was 94%.Serum levels of CITP were shown to be an independent and strong prognostic marker regarding survival in CHF patients. Furthermore, CITP levels had an additive prognostic value compared with NT-proBNP levels. These findings underline the detrimental role of myocardial fibrosis in the progression of heart failure and suggest a novel multi-marker approach for risk stratification in the CHF syndrome.