Contrast-Induced Nephropathy in STEMI Patients With and Without Chronic Kidney Disease

• DOI: 10.1097/hpc.0000000000000123
• Publication Date: 2018-02-11T12:48:11Z
• Authors: Tarun Jain; Sunay Shah; Jainil Shah; Gordon Jacobsen; Akshay Khandelwal
• Keywords: Contrast-Induced Nephropathy

Contrast-induced nephropathy (CIN) following percutaneous coronary intervention (PCI) is associated with adverse outcomes; however, there are scarce data comparing clinical outcomes of post-PCI CIN in ST elevation myocardial infarction (STEMI) patients and without chronic kidney disease (CKD). We sought to assess the incidence, predictors, short-term long-term STEMI CKD.We performed a retrospective observational cohort study involving 554 who underwent PCI for from February 2010 November 2013. CKD was defined as estimated glomerular filtration rate ≤60 mL/min creatinine increase by ≥25% or ≥0.5 mg/dL baseline within 72 hours after catheterization contrast exposure.In entire population, developed 89 (16%) patients. The incidence 19.7% (27/137) 11.1% (62/417) non-CKD patients, P < 0.05. Univariate analysis predictors were older age (65 vs. 60 years), diabetes (35% 21%), peripheral artery (11% 5%), cardiogenic shock (24% 13%), hemodynamic support placement (34% 14%), Mehran score (9.4 ± 7 5.4 5.2) all same across exception diabetes. In multivariate analysis, strongest predictor (odds ratio, 5.8; CI, 1.8-18.6); not population. each single unit 1.1 times greater likelihood 1.1; 1.01-1.2). Patients had higher rates inpatient mortality (14.6% 2.8%), longer length hospitalization (8 11 3.4 4.4 days), need dialysis (11.2% 0%), 30-day 3.0%), serum >0.5 (16.9% 2.4%) 0.05.Overall, we found that undergoing have than confers worse irrespective renal function.