ASSOCIATION OF LOC387715 A69S GENOTYPE WITH VISUAL PROGNOSIS AFTER PHOTODYNAMIC THERAPY FOR POLYPOIDAL CHOROIDAL VASCULOPATHY

• DOI: 10.1097/iae.0b013e3181e587e3
• Publication Date: 2010-07-28T06:57:42Z
• Authors: Yoichi Sakurada; Takeo Kubota; Mitsuhiro Imasawa; Fumihiko Mabuchi; Naohiko Tanabe; Hiroyuki Iijima
• Keywords: Aged, 80 and over; Indocyanine Green; Male; Peripheral Vascular Diseases; Photosensitizing Agents; Porphyrins; Genotype; Choroid; Proteins; Choroid Diseases; Middle Aged; Prognosis; 03 medical and health sciences; 0302 clinical medicine; Photochemotherapy; Pharmacogenetics; Humans; Female; Fluorescein Angiography; Coloring Agents; Aged; Follow-Up Studies

To investigate whether there is an association of the LOC387715 A69S genotype with visual prognosis after photodynamic therapy in eyes polypoidal choroidal vasculopathy (PCV).Photodynamic was repeated every 3 months until disappearance angiographic signs active lesions 71 patients PCV who were followed-up for at least 12 months. All genotyped polymorphism (rs10490924, risk-allele T).Although no statistically significant difference mean baseline acuity (P = 0.53) among genotypes, a both 12-month and final visits 0.002 P < 0.001, respectively) poorer higher "T-"allele frequency. "T" allele more frequently observed those recurred (odds ratio: 5.8, 95% confidential interval: 2.3-15.1, T vs. G).There pharmacogenetic between variant long-term results PCV. The clinical importance to predict These should be confirmed or refuted by replication studies.