INTRAOCULAR ACTIVATION OF ANGIOGENIC AND INFLAMMATORY PATHWAYS IN UVEAL MELANOMA

• DOI: 10.1097/iae.0b013e318239e299
• Publication Date: 2012-03-14T12:57:55Z
• Authors: Roman Dunavoelgyi; Marion Funk; Stefan Sacu; Michael Georgopoulos; Gerhard Zlabinger; Martin Zehetmayer; Ursula Schmidt-Er...
• Keywords: Male; Uveal Neoplasms; Eye Enucleation; Aqueous Humor; Vitreous Body; 03 medical and health sciences; Monosomy; 0302 clinical medicine; Cytokines; Humans; Angiogenesis Inducing Agents; Female; Chromosomes, Human, Pair 3; Prospective Studies; Melanoma; Aged

To identify and quantify angiogenic inflammatory cytokines in aqueous vitreous humor eyes with untreated uveal melanoma to analyze clinicopathologic correlations.Intraocular fluid samples of patients (uveal n = 21, 34) controls (cataract 41, vitreomacular traction 35, 36) were taken intraoperatively analyzed using Luminex xMAP suspension array technology. Beadlyte kits used for detection 28 different cytokines.Flt-3 ligand, interleukin (IL) 1α, IL-6, IL-8, interferon-γ inducible protein (IP)-10, monocyte chemoattractant 1 (MCP-1), macrophage platelet-derived growth factor AA, vascular endothelial significantly elevated when compared controls. Eotaxin was aqueous, IL-7 RANTES eyes. Interferon-γ 10, 1α (aqueous vitreous), Flt-3 MCP-1 (vitreous) correlated tumor dimensions. Further correlations found between infiltration Bruch membrane AA (vitreous). Analyzing 16 paired samples, IL-7, MCP-1, vitreous, IL-1α samples.A range angiogenic, inflammatory, chemotactic supports the link inflammation tumorigenesis.