RELEASE AND VELOCITY OF MICRONIZED DEXAMETHASONE IMPLANTS WITH AN INTRAVITREAL DRUG DELIVERY SYSTEM

• DOI: 10.1097/iae.0b013e31825699e5
• Publication Date: 2012-10-11T14:20:54Z
• Authors: Carsten H. Meyer; Adrian Klein; Florian Alten; Zengping Liu; Boris V. Stanzel; Hans M. Helb; Christian K. Brin...
• Keywords: Millisecond

Ozurdex, a novel dexamethasone (DEX) implant, is released by drug delivery system into the vitreous cavity. We analyzed mechanical release aperture of applicator, obtained real-time recordings using high-speed camera and performed kinematic analysis DEX application.Experimental study.: The application intravitreal implants (6 mm length, 0.46 diameter; 700 μg mass, 0.0012 g total implant mass) was recorded (500 frames per second) in water (Group A: n = 7) or B: filled tanks. Kinematic calculated initial muzzle velocity as well impact on retinal surface at approximately 15 injected both groups. A series positions graphically plotted over time.High-speed revealed that entire movement lasted between 28 milliseconds 55 Group 1 millisecond 7 B. moved with mean 820 ± 350 mm/s (±SD, range, 326-1,349 mm/s) 817 307 373-1,185 In groups, gradually decelerated because drag force. With greater distances, decreased exponentially to complete stop 13.9 24.7 6.4 8.0 Five reached distance more than mm, their 408 145 322-667 mm/s), consecutive normalized energy 0.55 0.44 J/m (±SD). B, none 6 more. An accidental an angle 30 grade consecutively reduced may result 844 0.15 (SD 0.47) water-filled eye.The 0.8 m/s decreases distance. time faster water. does not reach reported damage levels for direct foreign bodies other projectiles.