Effect of Beclomethasone Nasal Spray on Intraocular Pressure in Ocular Hypertension or Controlled Glaucoma

• DOI: 10.1097/ijg.0b013e3182254811
• Publication Date: 2011-06-29T11:48:26Z
• Authors: Darana Yuen; Yvonne M. Buys; Ya-Ping Jin; Tariq Alasbali; Graham E. Trope
• Keywords: Nasal spray; Clinical endpoint

To evaluate the effect of 6 weeks administration beclomethasone nasal spray on intraocular pressure (IOP) in patients with ocular hypertension or controlled primary open-angle glaucoma.Randomized double-masked trial. Patients were randomized to twice daily versus placebo saline spray. There a total 4 study visits: baseline and 2, 4, after starting Each visit was at same time within 1-hour window. Primary outcome measure IOP. Secondary measures included visual acuity, anterior segment changes, patient reported side effects, compliance. Study endpoint from start treatment an IOP increase >20% baseline. A sample size calculation suggested that 8 each arm would be sufficient detect difference 3.2 mm Hg power 80%.Nineteen consecutive consenting completed study-9 steroid 10 arm. no statistically significant differences between groups characteristics, visit, change any point. At weeks, mean +0.50±1.52 +0.70±1.44 groups, respectively (P=0.77).Patients glaucoma showed evidence elevation use